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Msmr2MSM/Ms
QTL Variant Detail
Summary
QTL variant: Msmr2MSM/Ms
Name: MSM lymphoma resistance 2; MSM/Ms
MGI ID: MGI:3609168
QTL: Msmr2  Location: Chr18:54975873-61238870 bp  Genetic Position: Chr18, Syntenic
Variant
origin
Strain of Specimen:  MSM/Ms
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers lymphoma resistance compared to SL/Kh. (J:34941)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:34941

All the chromosomes of progeny from a (MSM/Ms x SL/Kh)F1 x SL/Kh backcross were scanned for linkage of lymphoma susceptibility with 79 polymorphic microsatellite loci spaced 15 cM - 30 cM apart. Authors found a significant linkage disequilibrium in the proximal segment of mouse Chromosome 18, between D18Mit90 (28 cM) and D18Mit140 (37 cM) These data map Msmr2 between D18Mit90 and D18Mit140 on mouse Chromosome 18. The MSM/Ms-derived allele at Msmr2 is associated with dominant lymphoma resistance whereas the SL/Kh-derived allele is associated with susceptibility.

References
Original:  J:34941 Pataer A, et al., Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 1996 Aug 15;56(16):3716-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory