Cbln1^tm1Jim
Targeted Allele Detail

Summary

• Symbol: Cbln1^tm1Jim
• Name: cerebellin 1 precursor protein; targeted mutation 1, James I Morgan
• MGI ID: MGI:3609188
• Synonyms: cbln1^-
• Gene: Cbln1 Location: Chr8:88195481-88199220 bp, - strand Genetic Position: Chr8, 42.16 cM
• Alliance: Cbln1^tm1Jim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102516
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to insert a neomycin resistance gene downstream of the start codon, resulting in the replacement of four nucleotides from the third nucleotide of codon 28 to codon 29. Ablation of the locus was confirmed by Northern blot, radioimmunoassay and imunoblot. (J:102516)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbln1 Mutation: 15 strains or lines available

References

• Original: J:102516 Hirai H, et al., Cbln1 is essential for synaptic integrity and plasticity in the cerebellum. Nat Neurosci. 2005 Nov;8(11):1534-41
• All: 17 reference(s)