Fanca^tm1Zqw
Targeted Allele Detail

Summary

• Symbol: Fanca^tm1Zqw
• Name: Fanconi anemia, complementation group A; targeted mutation 1, Zhao-Qi Wang
• MGI ID: MGI:3609190
• Synonyms: Fanca^delta
• Gene: Fanca Location: Chr8:123995039-124045315 bp, - strand Genetic Position: Chr8, 72.1 cM
• Alliance: Fanca^tm1Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102526
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance gene flanked by loxP sites was inserted into intron 36 and a third loxP site was inserted into intron 39. Transient transfection with cre recombinase resulted in the loss of exons 37-39. Western blot failed to detect protein in ES cells and fibroblasts. (J:102526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fanca Mutation: 81 strains or lines available

References

• Original: J:102526 Yang YG, et al., The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis. 2005 Oct;26(10):1731-40
• All: 1 reference(s)