Apoc3^tm1Lap
Targeted Allele Detail

Summary

• Symbol: Apoc3^tm1Lap
• Name: apolipoprotein C-III; targeted mutation 1, Len A Pennacchio
• MGI ID: MGI:3609193
• Gene: Apoc3 Location: Chr9:46144348-46146934 bp, - strand Genetic Position: Chr9, 25.36 cM
• Alliance: Apoc3^tm1Lap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102319
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: ES cells with a hygromycin resistance gene replacing the entire Apoa5 locus were targeted a second time with a vector designed to replace exon 4 of Apoc3 with a neomycin resistance gene. Northern blot revealed that the mutant mice lacked both Apoa5 and Apoc3 transcripts. (J:102319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apoc3 Mutation: 19 strains or lines available

References

• Original: J:102319 Baroukh N, et al., Analysis of apolipoprotein A5, c3, and plasma triglyceride concentrations in genetically engineered mice. Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1297-302
• All: 1 reference(s)