Cacng8^tm1Ran
Targeted Allele Detail

Summary

• Symbol: Cacng8^tm1Ran
• Name: calcium channel, voltage-dependent, gamma subunit 8; targeted mutation 1, Roger A Nicoll
• MGI ID: MGI:3609205
• Synonyms: gamma-8^-, TARP gamma-8^-
• Gene: Cacng8 Location: Chr7:3442558-3464782 bp, + strand Genetic Position: Chr7, 1.98 cM
• Alliance: Cacng8^tm1Ran page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102515
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The locus was disrupted by the replacement of exons 2 and 3 with a neomycin resistance gene. Quantitative immunoblot of hippocampal extracts of mutants confirms the absence of protein. (J:102515)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacng8 Mutation: 31 strains or lines available

References

• Original: J:102515 Rouach N, et al., TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity. Nat Neurosci. 2005 Nov;8(11):1525-33
• All: 10 reference(s)