Lar^SAMP1
QTL Variant Detail

Summary

• QTL variant: Lar^SAMP1
• Name: low antibody response; SAMP1
• MGI ID: MGI:3609236
• QTL: Lar Location: Chr7:33900755-33929761 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: SAMP1

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele is associated with low antibody response compared to C57BL/10. (J:1953)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:1953

Genetic linkage of low antibody response (Lar) with the albino locus on mouse Chromosome 7 was determined in 296 (B10.BR x SAMP1)F2 mice. Parental strain SAMP1 exhibits low antibody response when challenged with sheep or horse red blood cells whereas parental strain B10.BR exhibits normal antibody response. From a total of 72 albino mice 15 (20%) were low responders, whereas only 18 of 206 (8.0%) nonalbino mice were lowresponders. The correlation data provides a chi-square of 9.00 with a P of less than .01. Low antibody response in F2 animals shows linkage to Tyr (44 cM) on mouse Chromosome 7.

J:1953

Genetic linkage of low antibody response (Lar) with the Gpi1 locus on mouse Chromosome 7 was determined in 208 (B10.BR x SAM-P/1)F2 mice. Parental strain SAMP1 exhibits low antibody response when challenged with sheep or horse red blood cells whereas parental strain B10.BR exhibits normal antibody response. From a total of 24 low responders, 9 (37%) carried the Gpi-1 a/a genotype of the SAM-P/1 parent. Whereas of a 184 responders only 39 (21%) carried the SAM-P/1 Gpi-1 genotype. The correlation data aprovides a chi-square of 8.21 with a P of less than .01. Low antibody response in F2 animals shows linkage to Gpi1 (11 cM) on mouse Chromosome 7.

References

• Original: J:1953 Hanada K, et al., Immune responses in newly developed short-lived SAM mice. IV. Chromosomal location of a gene controlling defective helper T-cell activity. Immunology. 1991 Sep;74(1):160-4
• All: 1 reference(s)