Tlr1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tlr1^tm1Aki
• Name: toll-like receptor 1; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3609369
• Synonyms: Tlr1^-
• Gene: Tlr1 Location: Chr5:65082022-65090906 bp, - strand Genetic Position: Chr5, 33.53 cM
• Alliance: Tlr1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103395
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a portion of an exon containing amino acids 575-795 of the locus, sequence encoding the transmembrane and cytoplasmic regions of the protein. Northern blot failed to detect transcript in mutants. (J:103395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr1 Mutation: 52 strains or lines available

References

• Original: J:103395 Takeuchi O, et al., Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002 Jul 1;169(1):10-4
• All: 33 reference(s)