Ihh^tm1Blan
Targeted Allele Detail

Summary

• Symbol: Ihh^tm1Blan
• Name: Indian hedgehog; targeted mutation 1, Beate Lanske
• MGI ID: MGI:3609381
• Synonyms: Ihh^fl
• Gene: Ihh Location: Chr1:74984474-74990831 bp, - strand Genetic Position: Chr1, 38.55 cM
• Alliance: Ihh^tm1Blan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102870
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 1, followed by a frt-flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 1. Flp-mediated recombination removed the neo cassette. (J:102870)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ihh Mutation: 22 strains or lines available

References

• Original: J:102870 Razzaque MS, et al., Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J Pathol. 2005 Dec;207(4):453-61
• All: 25 reference(s)