Fabp3^tm1Jshr
Targeted Allele Detail

Summary

• Symbol: Fabp3^tm1Jshr
• Name: fatty acid binding protein 3, muscle and heart; targeted mutation 1, Jane Shearer
• MGI ID: MGI:3609428
• Gene: Fabp3 Location: Chr4:130202531-130209256 bp, + strand Genetic Position: Chr4, 63.43 cM
• Alliance: Fabp3^tm1Jshr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102858
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first two exons of the locus were replaced with an in-frame lacZ with an NLS. Immunoblot of heterozygous gastrocnemius demonstrated a reduced amount of protein. (J:102858)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fabp3 Mutation: 67 strains or lines available

References

• Original: J:102858 Shearer J, et al., Partial gene deletion of heart-type Fatty Acid-binding protein limits the severity of dietary-induced insulin resistance. Diabetes. 2005 Nov;54(11):3133-9
• All: 2 reference(s)