Slc5a3^tm1Skc
Targeted Allele Detail

Summary

• Symbol: Slc5a3^tm1Skc
• Name: solute carrier family 5 (inositol transporters), member 3; targeted mutation 1, Sookja K Chung
• MGI ID: MGI:3609547
• Synonyms: SMIT^-
• Gene: Slc5a3 Location: Chr16:91855210-91884361 bp, + strand Genetic Position: Chr16, 53.44 cM
• Alliance: Slc5a3^tm1Skc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102665
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace 680 bp near the 5' end of the coding region with a PGK-neo, removing amino acids 176 to 404 in the encoded protein. Transcript was absent in kidney and brains of mutant mice. (J:102665)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc5a3 Mutation: 24 strains or lines available

References

• Original: J:102665 Chau JF, et al., Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves. FASEB J. 2005 Nov;19(13):1887-9
• All: 1 reference(s)