Prox1^tm2Gco
Targeted Allele Detail

Summary

• Symbol: Prox1^tm2Gco
• Name: prospero homeobox 1; targeted mutation 2, Guillermo Oliver
• MGI ID: MGI:3609548
• Synonyms: Prox1^flox, Prox1^loxP
• Gene: Prox1 Location: Chr1:189850232-189902911 bp, - strand Genetic Position: Chr1, 95.85 cM
• Alliance: Prox1^tm2Gco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102652
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting construct was created to flank exons 2 and 3, sequence encoding the homeodomain and Prox domain, with loxP sites. Loss of this sequence would render the locus transcriptionally inactive. (J:102652)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prox1 Mutation: 43 strains or lines available

References

• Original: J:102652 Harvey NL, et al., Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet. 2005 Oct;37(10):1072-81
• All: 29 reference(s)