Adm^tm1Tfjt
Targeted Allele Detail

Summary

• Symbol: Adm^tm1Tfjt
• Name: adrenomedullin; targeted mutation 1, Toshiro Fujita
• MGI ID: MGI:3609557
• Synonyms: Adm^AM, AM^-
• Gene: Adm Location: Chr7:110226868-110229027 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Adm^tm1Tfjt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102946
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert a stop mutation at the beginning of the coding region at exon 4. A floxed tk-neo was included in the vector to be inserted into intron 1. The disruption was confirmed by the absence of immunoreactive protein in the mutant fetus. (J:102946)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Adm^tm1Tfjt/Adm^tm1Tfjt	involves: C57BL/6 * CBA
ht2	Adm^tm1Tfjt/Adm^+	involves: C57BL/6 * CBA

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms
cardiovascular system		√
abnormal coronary artery morphology		√
blood vessel inflammation		√
cellular		√
oxidative stress		√
immune system		√
blood vessel inflammation		√
mortality/aging	√
preweaning lethality, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adm Mutation: 13 strains or lines available

References

• Original: J:102946 Shimosawa T, et al., Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage. Circulation. 2002 Jan 1;105(1):106-11
• All: 4 reference(s)