Ptch1^tm1Kmmt
Targeted Allele Detail

Summary

• Symbol: Ptch1^tm1Kmmt
• Name: patched 1; targeted mutation 1, Hiroyuki Kumamoto
• MGI ID: MGI:3609560
• Synonyms: ptc^-
• Gene: Ptch1 Location: Chr13:63656142-63721274 bp, - strand Genetic Position: Chr13, 32.8 cM
• Alliance: Ptch1^tm1Kmmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102978
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 and 7 were replaced with an MC1-neomycin resistance gene via homologous recombination in ES cells. (J:102978)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptch1 Mutation: 115 strains or lines available

References

• Original: J:102978 Kimi K, et al., Immunohistochemical and genetic analysis of mandibular cysts in heterozygous ptc knockout mice. J Oral Pathol Med. 2003 Feb;32(2):108-13
• All: 1 reference(s)