Sgcg^tm1Oza
Targeted Allele Detail

Summary

• Symbol: Sgcg^tm1Oza
• Name: sarcoglycan, gamma (dystrophin-associated glycoprotein); targeted mutation 1, Eijiro Ozawa
• MGI ID: MGI:3609567
• Synonyms: gsg^-
• Gene: Sgcg Location: Chr14:61456564-61495939 bp, - strand Genetic Position: Chr14, 32.27 cM, cytoband C3
• Alliance: Sgcg^tm1Oza page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102780
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 3, which encodes the translation initiation site, the cytoplasmic domain, and the transmembrane domain of the encoded protein. Immunoblot analysis detected markedly reduced expression of alpha, beta and delta subunits and complete lack of the gamma subunit. (J:102780)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sgcg Mutation: 19 strains or lines available

References

• Original: J:102780 Sasaoka T, et al., Pathological analysis of muscle hypertrophy and degeneration in muscular dystrophy in gamma-sarcoglycan-deficient mice. Neuromuscul Disord. 2003 Mar;13(3):193-206
• All: 3 reference(s)