Apba1^tm1Amor
Targeted Allele Detail

Summary

• Symbol: Apba1^tm1Amor
• Name: amyloid beta precursor protein binding family A member 1; targeted mutation 1, Atsushi Mori
• MGI ID: MGI:3609568
• Gene: Apba1 Location: Chr19:23736251-23926960 bp, + strand Genetic Position: Chr19, 18.45 cM
• Alliance: Apba1^tm1Amor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102794
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.0-kb sequence containing the first methionine of the gene was replaced with the pMC1-neomycin-polyA cassette. Northern and Western blot analyses failed to detect transcript and protein, respectively, in mutant brain samples. (J:102794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apba1 Mutation: 32 strains or lines available

Notes

ES cell line = CCE28

References

• Original: J:102794 Mori A, et al., Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice. Neurosci Res. 2002 Jul;43(3):251-7
• All: 4 reference(s)