Slc8a1^tm2Kdp
Targeted Allele Detail

Summary

• Symbol: Slc8a1^tm2Kdp
• Name: solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 2, Kenneth D Philipson
• MGI ID: MGI:3609617
• Synonyms: NCX^-
• Gene: Slc8a1 Location: Chr17:81680534-82045806 bp, - strand Genetic Position: Chr17, 51.29 cM
• Alliance: Slc8a1^tm2Kdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103484
• Parent Cell Line: LW1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2, containing 64% of the coding sequence including the transcriptional start site, was deleted via cre mediated recombination. Immunoblot failed to detect protein in mutant embryo hearts. (J:103484)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc8a1 Mutation: 55 strains or lines available

References

• Original: J:103484 Reuter H, et al., The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circ Res. 2002 Feb 22;90(3):305-8
• All: 4 reference(s)