Adamts1^tm1Mlia
Targeted Allele Detail

Summary

• Symbol: Adamts1^tm1Mlia
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 1; targeted mutation 1, M Luisa Iruela-Arispe
• MGI ID: MGI:3609982
• Gene: Adamts1 Location: Chr16:85590715-85600001 bp, - strand Genetic Position: Chr16, 48.2 cM, cytoband C3-C5
• Alliance: Adamts1^tm1Mlia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102464
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to replace exons 2-8 with a loxP flanked neomycin resistance cassette. Fluorescence immunohistochemical analysis failed to detect protein in mutant. (J:102464)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts1 Mutation: 66 strains or lines available

References

• Original: J:102464 Lee NV, et al., Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem. 2005 Oct 14;280(41):34796-804
• All: 7 reference(s)