Abcb1b^tm1Bor
Targeted Allele Detail

Summary

• Symbol: Abcb1b^tm1Bor
• Name: ATP-binding cassette, sub-family B member 1B; targeted mutation 1, Piet Borst
• MGI ID: MGI:3610191
• Gene: Abcb1b Location: Chr5:8848147-8916314 bp, + strand Genetic Position: Chr5, 3.43 cM, cytoband A2-A3
• Alliance: Abcb1b^tm1Bor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39804
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: ES cells containing a previously targeted Abcb1a allele (Abcb1a^tm1Bor) were targeted again with a vector replacing exons 3 and 4 of Abcb1b with a neomycin selection cassette. The vector contained a MluI linker 3' of the neo cassette that allowed detection of the Abcb1b disruption linked to the previous Abcb1a disruption by long-range restriction mapping. (J:39804)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Abcb1b^tm1Bor

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Abcb1b Mutation: 84 strains or lines available

References

• Original: J:39804 Schinkel AH, et al., Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4028-33
• All: 76 reference(s)