Mybl2^tm1Jof
Targeted Allele Detail

Summary

• Symbol: Mybl2^tm1Jof
• Name: myeloblastosis oncogene-like 2; targeted mutation 1, Jon Frampton
• MGI ID: MGI:3610475
• Synonyms: B-myb^loxneo
• Gene: Mybl2 Location: Chr2:162896607-162926608 bp, + strand Genetic Position: Chr2, 84.0 cM
• Alliance: Mybl2^tm1Jof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103413
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed such that loxP sites were inserted just 5' of exon 2 and 3' of exon 5, thereby flanking all sequence encoding the DNA binding domain. A PGK-neo flankedby FRT sites was inserted into intron 3. This allele may be a weak hypomorph. (J:103413)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mybl2 Mutation: 114 strains or lines available

References

• Original: J:103413 Garcia P, et al., Generation of a conditional allele of the B-myb gene. Genesis. 2005 Dec;43(4):189-95
• All: 1 reference(s)