Angptl3^tm1Akos
Targeted Allele Detail

Summary

• Symbol: Angptl3^tm1Akos
• Name: angiopoietin-like 3; targeted mutation 1, Anja Koster
• MGI ID: MGI:3610614
• Synonyms: Angptl3^-
• Gene: Angptl3 Location: Chr4:98919191-98926429 bp, + strand Genetic Position: Chr4, 45.6 cM
• Alliance: Angptl3^tm1Akos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103363
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to remove 1.3 kb of sequence, including exon 1 containing the start codon. Northern blot failed to detect transcript in mutant liver tissue. (J:103363)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angptl3 Mutation: 36 strains or lines available

References

• Original: J:103363 Koster A, et al., Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology. 2005 Nov;146(11):4943-50
• All: 1 reference(s)