Polq^tm1Jcs
Targeted Allele Detail

Summary

• Symbol: Polq^tm1Jcs
• Name: polymerase (DNA directed), theta; targeted mutation 1, John C Schimenti
• MGI ID: MGI:3610670
• Synonyms: Polq^-
• Gene: Polq Location: Chr16:36832148-36915779 bp, + strand Genetic Position: Chr16, 26.32 cM, cytoband B4
• Alliance: Polq^tm1Jcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94088
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert an in-frame stop codon into exon 1 and replace exons 2-5 with a neomycin resistance gene. (J:94088)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Polq Mutation: 127 strains or lines available

References

• Original: J:94088 Shima N, et al., The Mouse Genomic Instability Mutation chaos1 Is an Allele of Polq That Exhibits Genetic Interaction with Atm. Mol Cell Biol. 2004 Dec;24(23):10381-9
• All: 11 reference(s)