Cbl^tm2Wlan
Targeted Allele Detail

Summary

• Symbol: Cbl^tm2Wlan
• Name: Casitas B-lineage lymphoma; targeted mutation 2, Wallace Y Langdon
• MGI ID: MGI:3610727
• Synonyms: A, c-Cbl^A, c-Cbl(C379A)
• Gene: Cbl Location: Chr9:44054273-44145346 bp, - strand Genetic Position: Chr9, 24.72 cM
• Alliance: Cbl^tm2Wlan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103366
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A point mutation resulted in a cysteine to alanine substitution at position 379 (C379A). Western blot showed that protein levels in thymocytes were not affected by the mutation. (J:103366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cbl Mutation: 59 strains or lines available

References

• Original: J:103366 Thien CB, et al., Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J. 2005 Nov 2;24(21):3807-19
• All: 9 reference(s)