Apoe^{tm3(APOE_i3)Sfu}
Targeted Allele Detail

Summary

• Symbol: Apoe^{tm3(APOE_i3)Sfu}
• Name: apolipoprotein E; targeted mutation 1, Shinobu C Fujita
• MGI ID: MGI:3610994
• Synonyms: 3/3, apoE3, ApoE3-KI, Apoe^{tm1(APOE)Kyan}, Apoe^{tm3(APOE3)sfu}
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^{tm3(APOE_i3)Sfu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103515
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Apoe^{tm3(APOE_i3)Sfu} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

  Expresses the epsilon3 isoform

• Mutation details: A portion of the endogenous locus, spanning from within exon 2 through most of exon 4, was replaced by the human cDNA encoding APOE isoform 3. Mouse protein was not detected in Western blot of mutants. Human protein was shown to be robustly expressed. (J:103515)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 156 strains or lines available

References

• Original: J:103515 Hayashi H, et al., Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice. Neuroreport. 2002 Mar 25;13(4):383-6
• All: 9 reference(s)