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Apoetm3(APOE_i3)Sfu
Targeted Allele Detail
Summary
Symbol: Apoetm3(APOE_i3)Sfu
Name: apolipoprotein E; targeted mutation 1, Shinobu C Fujita
MGI ID: MGI:3610994
Synonyms: 3/3, apoE3, ApoE3-KI, Apoetm1(APOE)Kyan, Apoetm3(APOE3)sfu
Gene: Apoe  Location: Chr7:19430034-19433113 bp, - strand  Genetic Position: Chr7, 9.94 cM
Alliance: Apoetm3(APOE_i3)Sfu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103515
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Apoetm3(APOE_i3)Sfu expresses 1 gene
 
Mutation detailsA portion of the endogenous locus, spanning from within exon 2 through most of exon 4, was replaced by the human cDNA encoding APOE isoform 3. Mouse protein was not detected in Western blot of mutants. Human protein was shown to be robustly expressed. (J:103515)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  158 strains or lines available
References
Original:  J:103515 Hayashi H, et al., Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice. Neuroreport. 2002 Mar 25;13(4):383-6
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory