Gabbr2^tm1Bet
Targeted Allele Detail

Summary

• Symbol: Gabbr2^tm1Bet
• Name: gamma-aminobutyric acid type B receptor subunit 2; targeted mutation 1, Bernhard Bettler
• MGI ID: MGI:3610995
• Synonyms: GABAB(2)^-, GABAB2^-
• Gene: Gabbr2 Location: Chr4:46662318-46991714 bp, - strand Genetic Position: Chr4, 25.18 cM
• Alliance: Gabbr2^tm1Bet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct was designed to replace exons 9 and 10 with a neomycin resistance cassette by homologous recombination. This sequence encoded part of the N-terminal and the transmembrane domains 1 and 2. Northern blot failed to detect transcript in mutant brain samples. Immunoblot failed to detect protein in mutant brain samples. (J:103989)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabbr2 Mutation: 62 strains or lines available

References

• Original: J:103989 Gassmann M, et al., Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J Neurosci. 2004 Jul 7;24(27):6086-97
• All: 9 reference(s)