Pam^tm1Jep
Targeted Allele Detail

Summary

• Symbol: Pam^tm1Jep
• Name: peptidylglycine alpha-amidating monooxygenase; targeted mutation 1, John E Pintar
• MGI ID: MGI:3610996
• Synonyms: PAM^-
• Gene: Pam Location: Chr1:97748816-98023578 bp, - strand Genetic Position: Chr1, 47.76 cM
• Alliance: Pam^tm1Jep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103533
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3, encompassing the translational start site and residues required for catalytic activity of the protein, were replaced with a neomycin resistance gene. (J:103533)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pam Mutation: 59 strains or lines available

References

• Original: J:103533 Czyzyk TA, et al., Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. Dev Biol. 2005 Nov 15;287(2):301-13
• All: 5 reference(s)