Tg(Myh6-ERBB4)HT2Gass
Transgene Detail

Summary

• Symbol: Tg(Myh6-ERBB4)HT2Gass
• Name: transgene insertion HT2, Martin Gassmann
• MGI ID: MGI:3611060
• Synonyms: HER4^heart, MHC-ErbB4
• Transgene: Tg(Myh6-ERBB4)HT2Gass Location: unknown
• Alliance: Tg(Myh6-ERBB4)HT2Gass page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-ERBB4)HT2Gass expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERBB4 (2066)

  Erbb4

  (MGI:104771)

• Mutation details: This transgene expresses a human ERBB4 gene under the control of a mouse alpha cardiac specific myosin heavy chain promoter. Expression was shown by RT-PCR in the adult heart. (J:84403)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
cn1	Erbb4^tm1Grl/Erbb4^tm1Grl Tg(Myh6-ERBB4)HT2Gass/0	B6.Cg-Erbb4^tm1Grl Tg(Myh6-ERBB4)HT2Gass
cx2	Erbb4^tm1Grl/Erbb4^tm1Grl Tg(Myh6-ERBB4)HT2Gass/0	involves: 129S1/Sv * 129X1/SvJ

Phenotypes:

Affected Systems	cn1	cx2
show or hide all annotated terms Sex:
behavior/neurological	√
behavior/neurological phenotype	N
impaired contextual conditioning behavior	√
impaired cued conditioning behavior	√
decreased anxiety-related response	√
increased locomotor activity	√
cardiovascular system		N	N
cardiovascular system phenotype		N	N
cellular		√	√
abnormal cranial neural crest cell migration		√	√
craniofacial		N	N
craniofacial phenotype		N	N
embryo		√	√
abnormal cranial neural crest cell migration		√	√
endocrine/exocrine glands		√
abnormal mammary gland development		√
abnormal mammary gland growth during pregnancy		√
abnormal mammary gland alveolus morphology		√
hypolactation		√
hematopoietic system		√	√
increased granulocyte number		√	√
immune system		√	√
increased granulocyte number		√	√
lung inflammation		√	√
integument		√
abnormal mammary gland development		√
abnormal mammary gland growth during pregnancy		√
abnormal mammary gland alveolus morphology		√
hypolactation		√
mortality/aging		√	√
perinatal lethality, incomplete penetrance		√	√
nervous system	√	√	√
nervous system phenotype		N	N
abnormal cerebellar granule layer morphology		√	√
abnormal cranial nerve morphology		√	√
abnormal long-term potentiation	√
enhanced long-term potentiation	√
decreased prepulse inhibition	√
reproductive system		√
abnormal mammary gland growth during pregnancy		√
respiratory system		√	√
lung inflammation		√	√
impaired lung alveolus development		√	√
abnormal pulmonary alveolar duct morphology		√	√
thick pulmonary interalveolar septum		√	√
abnormal respiratory function		√	√
decreased pulmonary respiratory rate		√	√
increased airway responsiveness		√	√
abnormal surfactant secretion		√	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:84403 Tidcombe H, et al., Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8281-6
• All: 36 reference(s)