Efs^tm1Kale
Targeted Allele Detail

Summary

• Symbol: Efs^tm1Kale
• Name: embryonal Fyn-associated substrate; targeted mutation 1, Konstantina Alexandropoulos
• MGI ID: MGI:3611072
• Synonyms: Sin^-
• Gene: Efs Location: Chr14:55153992-55163583 bp, - strand Genetic Position: Chr14, 27.99 cM, cytoband C1
• Alliance: Efs^tm1Kale page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103757
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the first exon, the first intron and part of the second exon, thus disrupting the structure of the Sin-SH3 domain. Protein was not detected in mutant thymus or brain by immunoblot analysis. (J:103757)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efs Mutation: 27 strains or lines available

References

• Original: J:103757 Donlin LT, et al., Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation. Mol Cell Biol. 2005 Dec;25(24):11035-46
• All: 5 reference(s)