Sphk2^tm1Rlp
Targeted Allele Detail

Summary

• Symbol: Sphk2^tm1Rlp
• Name: sphingosine kinase 2; targeted mutation 1, Richard L Proia
• MGI ID: MGI:3611080
• Synonyms: SK2^-, Sphk2^-
• Gene: Sphk2 Location: Chr7:45358891-45367426 bp, - strand Genetic Position: Chr7, 29.45 cM
• Alliance: Sphk2^tm1Rlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103755
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neo cassette replaced half of exon 4 through the end of exon 7 by homologous recombination. RT-PCR analysis of total RNA form adult tissues failed to detect transcript in mutants. (J:103755)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Sphk2 Mutation: 38 strains or lines available

References

• Original: J:103755 Mizugishi K, et al., Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005 Dec;25(24):11113-21
• All: 59 reference(s)