Lin7c^tm1Dsb
Targeted Allele Detail

Summary

• Symbol: Lin7c^tm1Dsb
• Name: lin-7 homolog C, crumbs cell polarity complex component; targeted mutation 1, David S Bredt
• MGI ID: MGI:3611209
• Synonyms: MALS-3 KO
• Gene: Lin7c Location: Chr2:109721205-109731348 bp, + strand Genetic Position: Chr2, 56.65 cM
• Alliance: Lin7c^tm1Dsb page

Lin7c^tm1Dsb/Lin7c^tm1Dsb mice display renal defects

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102649
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 3-5 with a neomycin resistance cassette. Western blot failed to detect protein in mutants. (J:102649)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lin7c Mutation: 17 strains or lines available

References

• Original: J:102649 Olsen O, et al., Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol. 2005 Sep 26;170(7):1127-34
• All: 3 reference(s)