Lama1^tm1Olf
Targeted Allele Detail

Summary

• Symbol: Lama1^tm1Olf
• Name: laminin, alpha 1; targeted mutation 1, Olivier Lefebvre
• MGI ID: MGI:3611212
• Synonyms: Lama1^flox
• Gene: Lama1 Location: Chr17:68004254-68129642 bp, + strand Genetic Position: Chr17, 38.8 cM
• Alliance: Lama1^tm1Olf page

The inner limiting membrane does not form in Lama1^tm1Olf/Lama1^tm1Olf Edil3^{Tg(Sox2-cre)1Amc}/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102740
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream and a PGK-neomycin selection cassette flanked by loxP and FRT sites 2 kb downstream of exon 1. The PGK-neo was excised by transient expression of FLP or cre recombinase. The loxP-flanked region encompasses part of the promoter region, the transcription start site, and the first exon. (J:102740)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lama1 Mutation: 186 strains or lines available

References

• Original: J:102740 Alpy F, et al., Generation of a conditionally null allele of the laminin alpha1 gene. Genesis. 2005 Oct;43(2):59-70
• All: 5 reference(s)