Gria3^tm1.1Rsp
Targeted Allele Detail

Summary

• Symbol: Gria3^tm1.1Rsp
• Name: glutamate receptor, ionotropic, AMPA3 (alpha 3); targeted mutation 1.1, Rolf Sprengel
• MGI ID: MGI:3611329
• Synonyms: GluR3^-, GluR-C^1lox, GRIA3^fl
• Gene: Gria3 Location: ChrX:40489731-40767478 bp, + strand Genetic Position: ChrX, 23.19 cM
• Alliance: Gria3^tm1.1Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104146
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was derived from Gria3^tm1Rsp by crossing mice carrying that allele with Tg(CMV-cre)1Cgn. This resulted in the excision of both the neomycin cassette and exon 11. Absence of gene product was confirmed by Western blot analysis of brain extracts. (J:104146)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gria3 Mutation: 12 strains or lines available

References

• Original: J:104146 Sanchis-Segura C, et al., Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. J Neurosci. 2006 Jan 25;26(4):1231-8
• All: 8 reference(s)