Gria2^tm3Rsp
Targeted Allele Detail

Summary

• Symbol: Gria2^tm3Rsp
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 3, Rolf Sprengel
• MGI ID: MGI:3611335
• Synonyms: GluA2^2lox, GluR2, GluR-B^2lox, GluR-B^f, GRIA2^fl
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm3Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103818
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP inserts are located both upstream and downstream of exon 11. A PGKneo cassette was also inserted but removed by electroporation of ES cells with a GFP-cre recombinase plasmid. (J:50929, J:103818, J:111689)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 79 strains or lines available

References

• Original: J:103818 Shimshek DR, et al., Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons. Mol Endocrinol. 2006 Jan;20(1):219-31
• All: 37 reference(s)