Rv3^CBA/Lac
QTL Variant Detail

Summary

• QTL variant: Rv3^CBA/Lac
• Name: Rauscher leukemia virus susceptibility 3; CBA/Lac
• MGI ID: MGI:3611356
• QTL: Rv3 Location: unknown Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: CBA/Lac

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to Rauscher leukemia virus compared to C57BL/6J. (J:7613)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7613

Among 30 males and 30 females from a cross CBA/Lac x C57BL/6J, there was no differences in number of spleen foci induced by Rauscher leukemia virus. From the reciprocal cross, C57BL/6J x CBA/Lac, males (N=38) had 1/4 the number of spleen loci as the females (N=52), indicating that the gene, Rv-3, is X-linked and C57BL/6J carries the recessive resistance allele and CBA/Lac carries the susceptibility allele.

References

• Original: J:7613 Heller E, et al., Chromosomal assignment of two murine genes controlling susceptibility to spleen focus formation by Rauscher leukemia virus. Exp Hematol. 1984 Sep;12(8):645-9
• All: 1 reference(s)