Rvil1^CE/J
QTL Variant Detail

Summary

• QTL variant: Rvil1^CE/J
• Name: radiation induced leukemia virus susceptibility; CE/J
• MGI ID: MGI:3611360
• QTL: Rvil1 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: CE/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to radiation induced leukemia virus compared to C57BL/10J. (J:7027)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7027

Susceptibility to radiation induced leukemia is determined by locus Rvil1. The assignment of this locus to Chromosome 2, between H-3 and a, was made by the analysis of susceptible congenic B10.CE-H3b^b/(30NX)SnDcr mice in which the locus Rvil1 was cotransferred from CE/J to the C57BL10/J background. An association of Chromosome 2 gene Ly-11 with Rvil-1 was also observed from progeny involving F2 crosses between A/J and C57BL/6J mice.

References

• Original: J:7027 Meruelo D, et al., Induction of leukemia by both fractionated x-irradiation and radiation leukemia virus involves loci in the chromosome 2 segment H-30-A. Proc Natl Acad Sci U S A. 1983 Jan;80(2):462-6
• All: 1 reference(s)