Summary |
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Variant origin |
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Variant description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:7027Induction of leukemia by fractionated doses of x-irradiation is determined by a gene or genes on mouse chromosomes. Evidence for a two gene model was determined by analysis of CXB RI lines in which line CXBG was more susceptible then either progenitor and (C57BL/6 x BALB/c)F1 mice were less susceptible then either parent. (Parental strain C57BL/6 is susceptible whereas parental strain BALB/c is resistant to fractionated X irradiation induced leukemia.) Analysis of B6.C-H30c congenic mice show a cotransfer of resistance with H30. The current locus for H30 is assigned to Chromosome 15. Authors assign H30 and the susceptibility locus Ril1 to Chromosome 2. 10.19.2015 Curator Note: Because Ril1 was originally mapped in J:6610, in 1981 using an (A/J x C57BL/10ScSn)F2 intercross, which differs from the mice used here, we consider the current study a separate mapping experiment and have named this QTL Ril4. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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