Ril4^BALB/c
QTL Variant Detail

Summary

• QTL variant: Ril4^BALB/c
• Name: radiation-induced leukemia sensitivity 4; BALB/c
• MGI ID: MGI:3611363
• QTL: Ril4 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to fractionated X-irradition induced leukemia compared to C57BL/6. (J:7027)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7027

Induction of leukemia by fractionated doses of x-irradiation is determined by a gene or genes on mouse chromosomes. Evidence for a two gene model was determined by analysis of CXB RI lines in which line CXBG was more susceptible then either progenitor and (C57BL/6 x BALB/c)F1 mice were less susceptible then either parent. (Parental strain C57BL/6 is susceptible whereas parental strain BALB/c is resistant to fractionated X irradiation induced leukemia.) Analysis of B6.C-H30^c congenic mice show a cotransfer of resistance with H30. The current locus for H30 is assigned to Chromosome 15. Authors assign H30 and the susceptibility locus Ril1 to Chromosome 2.

10.19.2015 Curator Note: Because Ril1 was originally mapped in J:6610, in 1981 using

an (A/J x C57BL/10ScSn)F2 intercross, which differs from the mice used here, we consider the current study a separate mapping experiment and have named this QTL Ril4.

References

• Original: J:7027 Meruelo D, et al., Induction of leukemia by both fractionated x-irradiation and radiation leukemia virus involves loci in the chromosome 2 segment H-30-A. Proc Natl Acad Sci U S A. 1983 Jan;80(2):462-6
• All: 1 reference(s)