Scl1^BALB/cHeA
QTL Variant Detail

Summary

• QTL variant: Scl1^BALB/cHeA
• Name: susceptibility to cutaneous leishmaniasis 1; BALB/cHeA
• MGI ID: MGI:3611367
• QTL: Scl1 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: BALB/cHeA

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:15298

Leishmania major infection in mice is controlled by genes on mouse chromosomes. Lesion diameter, spleen weight and liver parasite load were the parameters measured to show significant linkage to Chromosome 11, however no uniform strain distribution pattern was obtained across all experiments. One such locus, Scl1 was mapped in CXS RI lines to markers Il3, B4galnt2, Hoxb, Ccl2, Mtv3 and Es3 spanning 41 cM of Chromosome 11. Scl1 was not positioned with respect to the marker loci.

J:15299

Linkage analysis of animals from an (BALB/cAnPt x Rop/Le)F2 intercross and animals from several congenic strains showed that Scl1 is not linked to markers on mouse Chromosome 2, 4, 7, 8, 12, and 15. However, strain distribution pattern analysis of CXS (C=BALB/cHeAn; S=STS/A) recombinant inbred (RI) strains showed linkage of Scl1 to mouse Chromosome 11 near E3 (74 cM) and Tk1 (78 cM). Parental strain BALB/cHeAn is susceptible to infection by Leishmania major whereas parental strain STS/A is resistant.

The Scl1 locus is syntenic to human Chromosome 17q22-q25.

References

• Original: J:15299 Mock B, et al., Genetic control of Leishmania major infection in congenic, recombinant inbred and F2 populations of mice. Eur J Immunogenet. 1993 Oct;20(5):335-48
• All: 2 reference(s)