Scl2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Scl2^C57BL/6J
• Name: susceptibility to cutaneous leishmaniasis 2; C57BL/6J
• MGI ID: MGI:3611371
• QTL: Scl2 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to infection by Leishmania mexicana compared to DBA/2J. (J:12046)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:12046

Strain distribution pattern analysis of 12 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains showed linkage of susceptibility/resistance to infection with Leishmania mexicana to mouse Chromosome 4 near marker Xmmv8 (17.2 cM), Lyb4 (24.8 cM), Mup1 (27.8 cM), and Cd72 (22.5 cM). Parental strain C57BL/6J is susceptible to L. mexicana infection compared to parental strain DBA/2J. C57BL/J-derived alleles at Scl2 appear to be associated with susceptibility to L. mexicana infection.

References

• Original: J:12046 Roberts M, et al., Genetic analysis of Leishmania mexicana infection in mice: single gene (Scl-2) controlled predisposition to cutaneous lesion development. J Immunogenet. 1990 Feb-Apr;17(1-2):89-100
• All: 1 reference(s)