Ssic1^C57BL/10J
QTL Variant Detail

Summary

• QTL variant: Ssic1^C57BL/10J
• Name: susceptibility to small intestinal cancer 1; C57BL/10J
• MGI ID: MGI:3611374
• QTL: Ssic1 Location: Chr4:137674005-137674151 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: C57BL/10J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to small intestinal cancers compared to O20/A. (J:26873)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:26873

Two mouse strains with identical H2 haplotypes were used to identify a gene for susceptibility to small intestinal cancer on mouse Chromosome 4. 67 N3 tumor bearing mice from a (B10.O20 x O20/A)F1 x B10.O20 N3 cross were genotyped using 86 SSLP markers. Susceptibility is conferred by homozygosity of a gene from strain B10.O20. The highest chi-square value was obtained for D4Mit158 (67 cM) a locus for which only 3 of the 67 tumor bearing mice were heterozygous. D4Mit158 is located on distal Chromosome 4. Authors use symbol Ssic1 to represent the locus for susceptibility to small intestinal cancer.

References

• Original: J:26873 Fijneman RJ, et al., A gene for susceptibility to small intestinal cancer, ssic1, maps to the distal part of mouse chromosome 4. Cancer Res. 1995 Jul 15;55(14):3179-82
• All: 1 reference(s)