Carg2^C57L/J
QTL Variant Detail

Summary

• QTL variant: Carg2^C57L/J
• Name: Candida albicans resistance gene 2; C57L/J
• MGI ID: MGI:3611482
• QTL: Carg2 Location: unknown

Variant origin

• Strain of Specimen: C57L/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:39424

The strain distribution patterns (SDPs) in 15 AKXL (AKR/J x C57L/J) RI strains suggest that at least two gene families facilitate the tissue damage caused by systemic infection of Candida albicans. One of these genes has been designated as Carg2. The SDPs of this locus, Carg2 does not significantly correlate with any known genetic marker currently mapped in the AKXL set.

The parental strain AKR/J exhibits greater susceptibility to infection by C. albicans compared to parental strain C57L/J.

References

• Original: J:39424 Ashman RB, et al., Evidence that two independent host genes influence the severity of tissue damage and susceptibility to acute pyelonephritis in murine systemic candidiasis. Microb Pathog. 1997 Mar;22(3):187-92
• All: 2 reference(s)