Rxrb^tm1Pcn
Targeted Allele Detail

Summary

• Symbol: Rxrb^tm1Pcn
• Name: retinoid X receptor beta; targeted mutation 1, Pierre Chambon
• MGI ID: MGI:3611570
• Synonyms: RXRbeta^L2
• Gene: Rxrb Location: Chr17:34250786-34257373 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Rxrb^tm1Pcn page

Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop a chronic skin inflammation

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102470
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites flank exons 3 and 4, which encode the B and C regions and the Nt amino acids of region D. (J:102470, J:109510)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxrb Mutation: 27 strains or lines available

References

• Original: J:102470 Li M, et al., Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14795-800
• All: 12 reference(s)