Keap1^tm2Mym
Targeted Allele Detail

Summary

• Symbol: Keap1^tm2Mym
• Name: kelch-like ECH-associated protein 1; targeted mutation 2, Masayuki Yamamoto
• MGI ID: MGI:3611748
• Synonyms: K1-Kd, Keap1^f, keap1^flox, Keap1-kd
• Gene: Keap1 Location: Chr9:21141026-21150628 bp, - strand Genetic Position: Chr9, 7.74 cM, cytoband A3
• Alliance: Keap1^tm2Mym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103791
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A targeting vector was created in which exons 4-6 were floxed with loxP sites. This region encodes the double glycine repeat domain. Excision of these exons is predicted to result in generation of a truncated form incapable of repressing Nfe2l2 activity. This allele has reduced expression of the protein and is hypomorphic. (J:103791, J:146190)

Expression

In Mice Carrying this Mutation:

5 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Keap1^tm2Mym

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Keap1 Mutation: 36 strains or lines available

References

• Original: J:103791 Okawa H, et al., Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochem Biophys Res Commun. 2006 Jan 6;339(1):79-88
• All: 74 reference(s)