Xdh^tm1Fink
Targeted Allele Detail

Summary

• Symbol: Xdh^tm1Fink
• Name: xanthine dehydrogenase; targeted mutation 1, Toren Finkel
• MGI ID: MGI:3611749
• Synonyms: Xor^-
• Gene: Xdh Location: Chr17:74190890-74257191 bp, - strand Genetic Position: Chr17, 45.25 cM
• Alliance: Xdh^tm1Fink page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103558
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was used to replace portions of exon 3 and exon 4 and the entire intron 3 with a neomycin resistance cassette via homologous recombination. Transcript was not detected in mutant livers by RT-PCR. Protein activity in postnatal livers was not detected in a flurometric assay. (J:103558)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xdh Mutation: 101 strains or lines available

References

• Original: J:103558 Ohtsubo T, et al., Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2. Circ Res. 2004 Nov 26;95(11):1118-24
• All: 6 reference(s)