Postn^tm1Sjc
Targeted Allele Detail

Summary

• Symbol: Postn^tm1Sjc
• Name: periostin, osteoblast specific factor; targeted mutation 1, Simon J Conway
• MGI ID: MGI:3611751
• Synonyms: Peri^lacZ, periostin^-, Postn^-, Postn^LacZ
• Gene: Postn Location: Chr3:54268530-54298458 bp, + strand Genetic Position: Chr3, 25.46 cM
• Alliance: Postn^tm1Sjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103753
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A promoterless IRES-lacZ-neo-loxP cassette replaced the translation start site and all of the first exon and about 300 bp of the first intron. Western blot analysis failed to detect protein in newborn mutants. Whole-embryo staining showed widespread expression, particularly within the peripheral nervous system, craniofacial region, dermis of the skin, and body cavities. (J:103753)

Disease models

Expression

In Mice Carrying this Mutation:	10 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Postn Mutation: 53 strains or lines available

References

• Original: J:103753 Rios H, et al., periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol. 2005 Dec;25(24):11131-44
• All: 30 reference(s)