Atxn2^tm1Plt
Targeted Allele Detail

Summary

• Symbol: Atxn2^tm1Plt
• Name: ataxin 2; targeted mutation 1, Stefan M Pulst
• MGI ID: MGI:3611805
• Synonyms: Sca2^-, SCA2^tm1SMP
• Gene: Atxn2 Location: Chr5:121849794-121954372 bp, + strand Genetic Position: Chr5, 61.93 cM, cytoband F
• Alliance: Atxn2^tm1Plt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103805
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 1 by homologous recombination. Exon 1 contained the translation start site. RT-PCR failed to detect transcripts in mutants. Protein was not detected by Western blot or immunocytochemical analyses of various tissues. (J:103805)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atxn2 Mutation: 90 strains or lines available

References

• Original: J:103805 Kiehl TR, et al., Generation and characterization of Sca2 (ataxin-2) knockout mice. Biochem Biophys Res Commun. 2006 Jan 6;339(1):17-24
• All: 7 reference(s)