Cdkn1b^tm2Jro
Targeted Allele Detail

Summary

• Symbol: Cdkn1b^tm2Jro
• Name: cyclin dependent kinase inhibitor 1B; targeted mutation 2, James M Roberts
• MGI ID: MGI:3611831
• Synonyms: P27^S10A
• Gene: Cdkn1b Location: Chr6:134897364-134902476 bp, + strand Genetic Position: Chr6, 65.77 cM
• Alliance: Cdkn1b^tm2Jro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103819
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The main phosphorylation site was changed from serine to alanine at amino acid position 10 by homologous recombination. (J:103819)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn1b^tm2Jro

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1b Mutation: 26 strains or lines available

References

• Original: J:103819 Besson A, et al., A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev. 2006 Jan 1;20(1):47-64
• All: 5 reference(s)