Kcnmb4^tm1Rwa
Targeted Allele Detail

Summary

• Symbol: Kcnmb4^tm1Rwa
• Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4; targeted mutation 1, Richard W Aldrich
• MGI ID: MGI:3611890
• Synonyms: Beta4^-, Beta4 KO, BK-Beta4 null
• Gene: Kcnmb4 Location: Chr10:116253766-116309783 bp, - strand Genetic Position: Chr10, 64.73 cM, cytoband D2
• Alliance: Kcnmb4^tm1Rwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with an eGFP-SV40-neo cassette. Elimination of the exon results in the loss of approximately half of the protein-coding region, including the first transmembrane domain. Northern blot did not detect transcript of the wild-type, but did detect transcript using an eGFP probe. (J:103931)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnmb4 Mutation: 24 strains or lines available

Notes

Relationship to Human Syndrome: Temporal lobe epilepsy

References

• Original: J:103931 Brenner R, et al., BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures. Nat Neurosci. 2005 Dec;8(12):1752-9
• All: 14 reference(s)