Ptprc^loc
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^loc
• Name: protein tyrosine phosphatase receptor type C; lochy
• MGI ID: MGI:3611894
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^loc page

Mutation origin

• Strain of Origin: C57BL/6JSfdAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered in an ENU mutagenesis screen. It comprises a T-to-A transversion at nucleotide 93085 of the genomic sequence, within an intron, which results in the insertion of the 5-base pair sequence ATCAG following nucleotide 1791 of the mRNA. This in turn causes a translational frame shift, introducing 26 new amino acids before a premature termination codon. No CD45/PTPRC protein is visually detectable on Western blot analysis of mutant thymocytes, and expression of CD45 is reduced on CD19⁺ B cells of homozygous mutant mice.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 189 strains or lines available

References

• Original: J:104190 The Australian Phenomics Facility at The Australian National University, Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University. MGI Direct Data Submission. 2006-2014
• All: 2 reference(s)