Smarca4^enu1
Chemically induced Allele Detail

Summary

• Symbol: Smarca4^enu1
• Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; enu1
• MGI ID: MGI:3611933
• Synonyms: Brg1^enu1, Smarca4^m1Mag
• Gene: Smarca4 Location: Chr9:21527465-21615526 bp, + strand Genetic Position: Chr9, 7.84 cM
• Alliance: Smarca4^enu1 page

Mutation origin

• Strain of Origin: C57BL/10

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: Males carrying the curly whisker allele were mutagenized with ENU to result in this hypomorphic allele. An A to G transition in exon 23 caused an E1083G substitution in a highly conserved region of the catalytic ATPase domain. The mutation did not affect mRNA or protein stability based on Orthern blot and Wesetern blot analyses, respectively. (J:103896)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smarca4 Mutation: 110 strains or lines available

References

• Original: J:103896 Bultman SJ, et al., A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005 Dec 1;19(23):2849-61
• All: 4 reference(s)