Hspa1b^tm1Bwy
Targeted Allele Detail

Summary

• Symbol: Hspa1b^tm1Bwy
• Name: heat shock protein 1B; targeted mutation 1, Byung-Woo Yoon
• MGI ID: MGI:3611984
• Synonyms: hsp70.1^-
• Gene: Hspa1b Location: Chr17:35175412-35178214 bp, - strand Genetic Position: Chr17, 18.5 cM
• Alliance: Hspa1b^tm1Bwy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103999
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.9-kb neomycin resistance gene was inserted to replace the promoter and some of the coding sequences, including the ATG. Northern blot failed to detect transcriupt in mutant mice. (J:103999)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspa1b Mutation: 24 strains or lines available

Notes

ES cell line = either E14 or BK4

References

• Original: J:103999 Lee SH, et al., Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice. Stroke. 2001 Dec 1;32(12):2905-12
• All: 2 reference(s)