Lsr1^A/J
QTL Variant Detail

Summary

• QTL variant: Lsr1^A/J
• Name: listeria resistance; A/J
• MGI ID: MGI:3612035
• QTL: Lsr1 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to infection by Listeria monocytogenes compared to C57BL/6J. (J:7345)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7345

Analysis of 13 AXB/BXA (A=A/J; B=C57BL/6J) recombinant inbred (RI) strains mapped resistance to Listeria monocytogenes to mouse Chromosome 2 near the Hc locus (23.5 cM). This locus is named Lsr1 (listeria resistance 1). Parental strain A/J is susceptibleto L. monocytogenes whereas parental strain C57BL/6J is resistant. The A/J-derived allele at Lsr1 confers susceptibility to L. monocytogenes and the C57BL/6J-derived allele at Lsr1 confers resistance. A second yet unmapped modifyier locus is believed to exist.

Interestingly, A/J and all of the susceptible AXB/BXA RI strains are deficient for hemolytic complement C5 encoded by Hc. Infusion of C5 into the serum of susceptible strain A/J conferred protection agains L. monocytogenes.

References

• Original: J:7345 Gervais F, et al., Genetic control of resistance to Listeria monocytogenes: regulation of leukocyte inflammatory responses by the Hc locus. J Immunol. 1984 Apr;132(4):2078-83
• All: 1 reference(s)